NICE Approval for Two Breast Cancer Drugs

Final draft guidance from NICE now recommends that two drugs to treat two different types of secondary or metastatic breast cancer be made available through the Cancer Drugs Fund.   Piqray or alpelisib is a kinase inhibitor made by Novartis Pharmaceuticals UK.  It is to be used with fulvestrant, the hormonal therapy, to treat hormone receptor…

Details

Walking the Wall

On 2nd August Catherine will set off from Wallsend, Newcastle-Upon-Tyne, to walk the length of Hadrian’s Wall to Bowness-on-Solway in Cumbria.  She hopes to complete the 100km distance from coast to coast across Northern England in eight days to raise money for Secondary1st.  The construction of Hadrian’s Wall began in 122 A.D. to guard the…

Details

A New Breast Cancer Drug

Results of a trial of Enhertu (trastuzumab deruxtecan) were presented at the 2022 meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine.  Enhertu is a specifically engineered HER2-directed antibody drug conjugate which looks for breast cancer cells, binds to the HER2 protein on their surface and then…

Details

Carol goes Ziplining at Eighty

On Sunday May 22nd, Carol will be riding the world’s fastest zip line in memory of her daughter, Nic. She will be joined on the zipline by Nolan and Ian and they will each reach speeds in excess of 100mph.  Carol aims to become the world’s fastest octogenarian, albeit briefly! They hope to raise as…

Details
secodary1st

All-Day Fundraiser

Shannon is organizing an All-Day Fundraiser at the Old Flower Shop in Mapperley on Saturday 14th May in aid of Secondary1st. She has arranged food and drink, a raffle with fabulous prizes, a bake sale and a tombola with even more prizes and the day is in honour of her Mum Sam.

Personalised Cancer Vaccines

With the knowledge gained from the mRNA vaccines generated for use against Coronavirus, scientists are working on the development of personalized cancer vaccines.  They know that every tumour is different and are progressing vaccines that are specific to each tumour and can be trained to recognize cancer cells so that they trigger an immune response.

Professor Klaus Pors

We are delighted to report that Klaus Pors has been promoted to Professor of Chemical Biology at the Institute of Cancer Therapeutics at the University of Bradford.  Professor Pors is leading the research team which includes Enrica, the PhD research student who has been funded for the past two years by Secondary1st, thanks to our…

Details

A New Test

Scientists are working on a ground-breaking test to spot or predict a woman’s risk of developing breast cancer or three other gynaecological cancers (ovarian, cervical and uterine cancer) from one sample taken from a routine cervical smear test.  Two papers published in the journal “Nature Communications” reported on two studies that found that this test,…

Details

Dr Seth Coffelt Update Dec 2021v1

Understanding how the immune system can help breast cancer to spread Dr Seth Coffelt, The Beatson Institute, University of Glasgow An update report prepared for Secondary1st, in recognition of your generous grant funding, December 2021 Available for download. Background Despite the great progress made in improving breast cancer diagnosis and treatments over the last few…

Details